Celgene psoriatic arthritis drug effective in trial
Thu Jul 12, 2012 8:51am EDT
(Reuters) – Celgene Corp said on Thursday its experimental treatment for psoriatic arthritis was effective in a late-stage clinical trial, with no significant safety issues.
The company said it expects to file for marketing approval of the drug, apremilast, in the first half of next year.
Psoriatic arthritis is a chronic, inflammatory disease that affects the joints and causes pain, stiffness and swelling. It is associated with the skin disorder, psoriasis.
The study, known as PALACE-1, is the first of three late-stage trials of the drug, a pill which inhibits an enzyme known as phosphodiesterase 4, or PDE4, and acts to damp down inflammation.
Celgene has also been testing apremilast for rheumatoid arthritis, but a Phase II pilot study of the drug in combination with the steroid methotrexate did not achieve its main goal. Data from a second Phase II trial testing the drug without methotrexate are expected in the third quarter of this year.
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Celgene psoriatic arthritis drug effective in trial
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